CATH Domain 6a47B01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.10	Ribonuclease H-like superfamily/Ribonuclease H

Domain Context

CATH Clusters

Superfamily	Ribonuclease H-like superfamily/Ribonuclease H
Functional Family	Three prime repair exonuclease 1

Enzyme Information

3.1.11.2

Exodeoxyribonuclease III.

based on mapping to UniProt Q9R1A9

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.

-!- Preference for double-stranded DNA. -!- Has endonucleolytic activity near apurinic sites on DNA. -!- Similar enzyme: Haemophilus influenzae exonuclease. -!- Formerly EC 3.1.4.27.

UniProtKB Entries (1)

Q9R1A9

TREX2_MOUSE

Mus musculus

Three prime repair exonuclease 2

PDB Structure

PDB	6A47
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural insights into the duplex DNA processing of TREX2 Cheng, H.L., Lin, C.T., Huang, K.W., Wang, S., Lin, Y.T., Toh, S.I., Hsiao, Y.Y. Nucleic Acids Res.