CATH Domain 5ylsA02

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1330	60s Ribosomal Protein L30; Chain: A;
	3.30.1330.20	Tubulin/FtsZ, C-terminal domain

Superfamily	Tubulin/FtsZ, C-terminal domain
Functional Family

E1BQ43	E1BQ43_CHICK Gallus gallus Uncharacterized protein
P63043	STMN4_RAT Rattus norvegicus Stathmin-4
P02554	TBB_PIG Sus scrofa Tubulin beta chain

PDB	5YLS
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in beta-tubulin. Yang, J.H., Yan, W., Yu, Y.M., Wang, Y.X., Yang, T., Xue, L.L., Yuan, X., Long, C.F., Liu, Z.W., Chen, X.X., Hu, M.S., Zheng, L., Qiu, Q., Pei, H.Y., Li, D., Wang, F., Bai, P., Wen, J.L., Ye, H.Y., Chen, L.J. J. Biol. Chem.