CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.510 | Transferase(Phosphotransferase); domain 1 | |
1.10.510.10 | Transferase(Phosphotransferase) domain 1 |
Domain Context
CATH Clusters
Superfamily | Transferase(Phosphotransferase) domain 1 |
Functional Family | cyclin-dependent kinase 8 isoform X1 |
Enzyme Information
2.7.11.23 |
[RNA-polymerase]-subunit kinase.
based on mapping to UniProt P49336
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.
-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.
|
2.7.11.22 |
Cyclin-dependent kinase.
based on mapping to UniProt P49336
ATP + a protein = ADP + a phosphoprotein.
-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.
|
UniProtKB Entries (1)
P49336 |
CDK8_HUMAN
Homo sapiens
Cyclin-dependent kinase 8
|
PDB Structure
PDB | 5XS2 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Discovery of potent and selective CDK8 inhibitors through FBDD approach
Bioorg. Med. Chem. Lett.
|