CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.505 | SHC Adaptor Protein |
|
3.30.505.10 | SH2 domain |
Domain Context
CATH Clusters
| Superfamily | SH2 domain |
| Functional Family | Tyrosine-protein phosphatase non-receptor type |
Enzyme Information
| 3.1.3.48 |
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q06124
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
|
UniProtKB Entries (2)
| Q06124 |
PTN11_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 11
|
| P55980 |
CAGA_HELPY
Helicobacter pylori 26695
Cytotoxicity-associated immunodominant antigen
|
PDB Structure
| PDB | 5X94 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Cell Rep
|