CATH Domain 5x7eA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.630	Cytochrome p450
	1.10.630.10	Cytochrome P450

Domain Context

CATH Clusters

Superfamily	Cytochrome P450
Functional Family	Cytochrome P450 monooxygenase

Enzyme Information

1.14.15.22

Vitamin D 1,25-hydroxylase.

based on mapping to UniProt P18326

(1) Calciol + O(2) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) = calcidiol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O. (2) Calcidiol + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = calcitriol + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O.

-!- An enzyme found in the bacterium Streptomyces griseolus. -!- Cf. EC 1.14.14.24 and EC 1.14.15.18.

UniProtKB Entries (1)

P18326

CPXE_STRGO

Streptomyces griseolus

Vitamin D3 dihydroxylase

PDB Structure

PDB	5X7E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Production of an active form of vitamin D2 by genetically engineered CYP105A1 Yasuda, K., Yogo, Y., Sugimoto, H., Mano, H., Takita, T., Ohta, M., Kamakura, M., Ikushiro, S., Yasukawa, K., Shiro, Y., Sakaki, T. Biochem. Biophys. Res. Commun.