CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.90 | Phospholipase A2 |
|
1.20.90.10 | Phospholipase A2 domain |
Domain Context
CATH Clusters
| Superfamily | Phospholipase A2 domain |
| Functional Family | Basic phospholipase A2 homolog |
Enzyme Information
| 3.1.1.4 |
Phospholipase A(2).
based on mapping to UniProt Q9NZK7
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate.
-!- Also acts on phosphatidylethanolamine, choline plasmalogen and phosphatides, removing the fatty acid attached to the 2-position.
|
UniProtKB Entries (1)
| Q9NZK7 |
PA2GE_HUMAN
Homo sapiens
Group IIE secretory phospholipase A2
|
PDB Structure
| PDB | 5WZW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE
Sci Rep
|
