CATH Domain 5wrlA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.1170	Mu homology domain, subdomain B

Domain Context

CATH Clusters

Superfamily	Mu homology domain, subdomain B
Functional Family	AP-2 complex subunit mu isoform 2

Enzyme Information

UniProtKB Entries (1)

IRS1_RAT

Rattus norvegicus

Insulin receptor substrate 1

PDB Structure

PDB	5WRL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling Yoneyama, Y., Lanzerstorfer, P., Niwa, H., Umehara, T., Shibano, T., Yokoyama, S., Chida, K., Weghuber, J., Hakuno, F., Takahashi, S.I. Elife