CATH Domain 5wfrN02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.840	Son of Sevenless (SoS) protein; Chain S, domain 2
	1.10.840.10	Ras guanine-nucleotide exchange factors catalytic domain

Domain Context

CATH Clusters

Superfamily	Ras guanine-nucleotide exchange factors catalytic domain
Functional Family	son of sevenless homolog 1 isoform X2

Enzyme Information

UniProtKB Entries (1)

RASH_HUMAN

Homo sapiens

GTPase HRas

PDB Structure

PDB	5WFR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Burns, M.C., Howes, J.E., Sun, Q., Little, A.J., Camper, D.V., Abbott, J.R., Phan, J., Lee, T., Waterson, A.G., Rossanese, O.W., Fesik, S.W. Anal. Biochem.