CATH Domain 5wbrB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1190	UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase
	3.40.1190.20	Ribokinase

Domain Context

CATH Clusters

Superfamily	3.40.1190.20
Functional Family	Ketohexokinase

Enzyme Information

2.7.1.3

Ketohexokinase.

based on mapping to UniProt P50053

ATP + D-fructose = ADP + D-fructose 1-phosphate.

-!- D-sorbose, D-agatose and 5-dehydro-D-fructose also act as acceptors.

UniProtKB Entries (1)

KHK_HUMAN

Homo sapiens

Ketohexokinase

PDB Structure

PDB	5WBR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). Huard, K., Ahn, K., Amor, P., Beebe, D.A., Borzilleri, K.A., Chrunyk, B.A., Coffey, S.B., Cong, Y., Conn, E.L., Culp, J.S., Dowling, M.S., Gorgoglione, M.F., Gutierrez, J.A., Knafels, J.D., Lachapelle, E.A., Pandit, J., Parris, K.D., Perez, S., Pfefferkorn, J.A., Price, D.A., Raymer, B., Ross, T.T., Shavnya, A., Smith, A.C., Subashi, T.A., Tesz, G.J., Thuma, B.A., Tu, M., Weaver, J.D., Weng, Y., Withka, J.M., Xing, G., Magee, T.V. J. Med. Chem.