1 keywords

CATH Domain 5w6eA00

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1300 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
Homologous Superfamily 1.10.1300.10 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family

Enzyme Information

3.1.4.17
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt Q01064
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.

UniProtKB Entries (1)

Q01064
PDE1B_HUMAN
Homo sapiens
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B

PDB Structure

PDB 5W6E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.
Humphrey, J.M., Movsesian, M., Am Ende, C.W., Becker, S.L., Chappie, T.A., Jenkinson, S., Liras, J.L., Liras, S., Orozco, C., Pandit, J., Vajdos, F.F., Vandeput, F., Yang, E., Menniti, F.S.
J. Med. Chem.