CATH Domain 5vlpA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.80	Peptidase S8 propeptide/proteinase inhibitor I9

Domain Context

CATH Clusters

Superfamily	Peptidase S8 propeptide/proteinase inhibitor I9
Functional Family	Proprotein convertase subtilisin/kexin type 9

Enzyme Information

3.4.21.-

Serine endopeptidases.

based on mapping to UniProt Q8NBP7

UniProtKB Entries (1)

PCSK9_HUMAN

Homo sapiens

Proprotein convertase subtilisin/kexin type 9

PDB Structure

PDB	5VLP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. Zhang, Y., Ultsch, M., Skelton, N.J., Burdick, D.J., Beresini, M.H., Li, W., Kong-Beltran, M., Peterson, A., Quinn, J., Chiu, C., Wu, Y., Shia, S., Moran, P., Di Lello, P., Eigenbrot, C., Kirchhofer, D. Nat. Struct. Mol. Biol.