CATH Domain 5vkcB01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.437	Apoptosis Regulator Bcl-x
	1.10.437.10	Blc2-like

Domain Context

CATH Clusters

Superfamily	Blc2-like
Functional Family	Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (1)

MCL1_HUMAN

Homo sapiens

Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB	5VKC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. Bruncko, M., Wang, L., Sheppard, G.S., Phillips, D.C., Tahir, S.K., Xue, J., Erickson, S., Fidanze, S., Fry, E., Hasvold, L., Jenkins, G.J., Jin, S., Judge, R.A., Kovar, P.J., Madar, D., Nimmer, P., Park, C., Petros, A.M., Rosenberg, S.H., Smith, M.L., Song, X., Sun, C., Tao, Z.F., Wang, X., Xiao, Y., Zhang, H., Tse, C., Leverson, J.D., Elmore, S.W., Souers, A.J. J. Med. Chem.