CATH Domain 5vebL01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.40	Immunoglobulin-like
	2.60.40.10	Immunoglobulins

Domain Context

CATH Clusters

Superfamily	Immunoglobulins
Functional Family	Immunoglobulin kappa chain variable 12-38

Enzyme Information

UniProtKB Entries (1)

CADH6_HUMAN

Homo sapiens

Cadherin-6

PDB Structure

PDB	5VEB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Bialucha, C.U., Collins, S.D., Li, X., Saxena, P., Zhang, X., Durr, C., Lafont, B., Prieur, P., Shim, Y., Mosher, R., Lee, D., Ostrom, L., Hu, T., Bilic, S., Rajlic, I.L., Capka, V., Jiang, W., Wagner, J.P., Elliott, G., Veloso, A., Piel, J.C., Flaherty, M.M., Mansfield, K.G., Meseck, E.K., Rubic-Schneider, T., London, A.S., Tschantz, W.R., Kurz, M., Nguyen, D., Bourret, A., Meyer, M.J., Faris, J.E., Janatpour, M.J., Chan, V.W., Yoder, N.C., Catcott, K.C., McShea, M.A., Sun, X., Gao, H., Williams, J., Hofmann, F., Engelman, J.A., Ettenberg, S.A., Sellers, W.R., Lees, E. Cancer Discov