CATH Domain 5v8oB01

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1410	Poly(a)-polymerase, middle domain
	1.10.1410.40

Superfamily	1.10.1410.40
Functional Family	Cyclic GMP-AMP synthase

2.7.7.86

Cyclic GMP-AMP synthase.

based on mapping to UniProt Q8N884

ATP + GTP = 2 diphosphate + cyclic G-P(2'-5')A-P(3'-5').

-!- Cyclic Gp(2'-5')Ap(3'-5') is a signaling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

CGAS_HUMAN

Homo sapiens

Cyclic GMP-AMP synthase

PDB	5V8O
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. Hall, J., Brault, A., Vincent, F., Weng, S., Wang, H., Dumlao, D., Aulabaugh, A., Aivazian, D., Castro, D., Chen, M., Culp, J., Dower, K., Gardner, J., Hawrylik, S., Golenbock, D., Hepworth, D., Horn, M., Jones, L., Jones, P., Latz, E., Li, J., Lin, L.L., Lin, W., Lin, D., Lovering, F., Niljanskul, N., Nistler, R., Pierce, B., Plotnikova, O., Schmitt, D., Shanker, S., Smith, J., Snyder, W., Subashi, T., Trujillo, J., Tyminski, E., Wang, G., Wong, J., Lefker, B., Dakin, L., Leach, K. PLoS ONE