CATH Domain 5v4wA02

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Superfamily	3.30.420.40
Functional Family	Phosphotransferase

2.7.1.2

Glucokinase.

based on mapping to UniProt P35557

ATP + D-glucose = ADP + D-glucose 6-phosphate.

-!- A group of enzymes found in invertebrates and microorganisms highly specific for glucose.

HXK4_HUMAN

Homo sapiens

Glucokinase

PDB	5V4W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. Cheruvallath, Z.S., Gwaltney, S.L., Sabat, M., Tang, M., Wang, H., Jennings, A., Hosfield, D., Lee, B., Wu, Y., Halkowycz, P., Grimshaw, C.E. Bioorg. Med. Chem. Lett.