CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.437 | Apoptosis Regulator Bcl-x |
|
1.10.437.10 | Blc2-like |
Domain Context
CATH Clusters
| Superfamily | Blc2-like |
| Functional Family | Bcl-2-related protein A1 |
Enzyme Information
UniProtKB Entries (1)
| Q16548 |
B2LA1_HUMAN
Homo sapiens
Bcl-2-related protein A1
|
PDB Structure
| PDB | 5UUK |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Elife
|