CATH Domain 5uq9G02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1040	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
	1.10.1040.10	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2

Domain Context

CATH Clusters

Superfamily	N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2
Functional Family	6-phosphogluconate dehydrogenase, decarboxylating

Enzyme Information

1.1.1.44

Phosphogluconate dehydrogenase (NADP(+)-dependent, decarboxylating).

based on mapping to UniProt P52209

6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO(2) + NADPH.

-!- The enzyme participates in the oxidative branch of the pentose phosphate pathway, whose main purpose is to produce NADPH and pentose for biosynthetic reactions. -!- Highly specific for NADP(+). -!- Cf. EC 1.1.1.343.

UniProtKB Entries (1)

P52209

6PGD_HUMAN

Homo sapiens

6-phosphogluconate dehydrogenase, decarboxylating

PDB Structure

PDB	5UQ9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Sun, Y., Bandi, M., Lofton, T., Smith, M., Bristow, C.A., Carugo, A., Rogers, N., Leonard, P., Chang, Q., Mullinax, R., Han, J., Shi, X., Seth, S., Meyers, B.A., Miller, M., Miao, L., Ma, X., Feng, N., Giuliani, V., Geck Do, M., Czako, B., Palmer, W.S., Mseeh, F., Asara, J.M., Jiang, Y., Morlacchi, P., Zhao, S., Peoples, M., Tieu, T.N., Warmoes, M.O., Lorenzi, P.L., Muller, F.L., DePinho, R.A., Draetta, G.F., Toniatti, C., Jones, P., Heffernan, T.P., Marszalek, J.R. Cell Rep