CATH Domain 5upeA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.70	Aldolase class I

Domain Context

CATH Clusters

Superfamily	Aldolase class I
Functional Family

Enzyme Information

2.4.2.12

Nicotinamide phosphoribosyltransferase.

based on mapping to UniProt P43490

Nicotinamide D-ribonucleotide + diphosphate = nicotinamide + 5-phospho- alpha-D-ribose 1-diphosphate.

UniProtKB Entries (1)

NAMPT_HUMAN

Homo sapiens

Nicotinamide phosphoribosyltransferase

PDB Structure

PDB	5UPE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT). Curtin, M.L., Heyman, H.R., Clark, R.F., Sorensen, B.K., Doherty, G.A., Hansen, T.M., Frey, R.R., Sarris, K.A., Aguirre, A.L., Shrestha, A., Tu, N., Woller, K., Pliushchev, M.A., Sweis, R.F., Cheng, M., Wilsbacher, J.L., Kovar, P.J., Guo, J., Cheng, D., Longenecker, K.L., Raich, D., Korepanova, A.V., Soni, N.B., Algire, M.A., Richardson, P.L., Marin, V.L., Badagnani, I., Vasudevan, A., Buchanan, F.G., Maag, D., Chiang, G.G., Tse, C., Michaelides, M.R. Bioorg. Med. Chem. Lett.