CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.3730 | ProC C-terminal domain-like fold |
|
1.10.3730.10 | ProC C-terminal domain-like |
Domain Context
CATH Clusters
| Superfamily | ProC C-terminal domain-like |
| Functional Family | Pyrroline-5-carboxylate reductase 1, mitochondrial |
Enzyme Information
| 1.5.1.2 |
Pyrroline-5-carboxylate reductase.
based on mapping to UniProt P32322
L-proline + NAD(P)(+) = 1-pyrroline-5-carboxylate + NAD(P)H.
-!- Also reduces 1-pyrroline-3-hydroxy-5-carboxylate to L-hydroxyproline.
|
UniProtKB Entries (1)
| P32322 |
P5CR1_HUMAN
Homo sapiens
Pyrroline-5-carboxylate reductase 1, mitochondrial
|
PDB Structure
| PDB | 5UAX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.
J. Biol. Chem.
|