CATH Domain 5uadA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Hepatocyte growth factor receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P08581

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08581

MET_HUMAN

Homo sapiens

Hepatocyte growth factor receptor

PDB Structure

PDB	5UAD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody. Farrell, P.J., Matuszkiewicz, J., Balakrishna, D., Pandya, S., Hixon, M.S., Kamran, R., Chu, S., Lawson, J.D., Okada, K., Hori, A., Mizutani, A., Iwata, H., de Jong, R., Hibner, B., Vincent, P. Mol. Cancer Ther.