1 keywords

CATH Domain 5u39A02

CATH Classification

Level CATH Code Description
Class 3 Alpha Beta
Architecture 3.30 2-Layer Sandwich
Topology 3.30.1700 lpxc deacetylase, domain 1
Homologous Superfamily 3.30.1700.10 lpxc deacetylase, domain 2

Domain Context

CATH Clusters

Superfamily lpxc deacetylase, domain 2
Functional Family

Enzyme Information

3.5.1.108
UDP-3-O-acyl-N-acetylglucosamine deacetylase.
based on mapping to UniProt P47205
UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
-!- The enzyme catalyzes a committed step in the biosynthesis of lipid A. -!- Formerly EC 3.5.1.n1.

UniProtKB Entries (1)

P47205
LPXC_PSEAE
Pseudomonas aeruginosa PAO1
UDP-3-O-acyl-N-acetylglucosamine deacetylase

PDB Structure

PDB 5U39
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC.
Piizzi, G., Parker, D.T., Peng, Y., Dobler, M., Patnaik, A., Wattanasin, S., Liu, E., Lenoir, F., Nunez, J., Kerrigan, J., McKenney, D., Osborne, C., Yu, D., Lanieri, L., Bojkovic, J., Dzink-Fox, J., Lilly, M.D., Sprague, E.R., Lu, Y., Wang, H., Ranjitkar, S., Xie, L., Wang, B., Glick, M., Hamann, L.G., Tommasi, R., Yang, X., Dean, C.R.
J. Med. Chem.