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CATH Classification

Domain Context

CATH Clusters

Superfamily S-adenosylmethionine decarboxylase
Functional Family S-adenosylmethionine decarboxylase proenzyme

Enzyme Information

4.1.1.50
Adenosylmethionine decarboxylase.
based on mapping to UniProt Q587A7
S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO(2).

UniProtKB Entries (1)

Q587A7
Q587A7_TRYB2
Trypanosoma brucei brucei TREU927
S-adenosylmethionine decarboxylase proenzyme

PDB Structure

PDB 5TVF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Volkov, O.A., Kinch, L., Ariagno, C., Deng, X., Zhong, S., Grishin, N., Tomchick, D.R., Chen, Z., Phillips, M.A.
Elife
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