CATH Domain 5tuyB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.270	Beta-clip-like
	2.170.270.10	SET domain

Domain Context

CATH Clusters

Superfamily	SET domain
Functional Family	Euchromatic histone-lysine N-methyltransferase 2

Enzyme Information

2.1.1.43	Histone-lysine N-methyltransferase. based on mapping to UniProt Q96KQ7 S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
2.1.1.-	Methyltransferases. based on mapping to UniProt Q96KQ7

UniProtKB Entries (1)

EHMT2_HUMAN

Homo sapiens

Histone-lysine N-methyltransferase EHMT2

PDB Structure

PDB	5TUY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. Xiong, Y., Li, F., Babault, N., Dong, A., Zeng, H., Wu, H., Chen, X., Arrowsmith, C.H., Brown, P.J., Liu, J., Vedadi, M., Jin, J. J. Med. Chem.