CATH Domain 5ttuA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase JAK2

Enzyme Information

2.7.10.2

Non-specific protein-tyrosine kinase.

based on mapping to UniProt P52333

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P52333

JAK3_HUMAN

Homo sapiens

Tyrosine-protein kinase JAK3

PDB Structure

PDB	5TTU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. Thorarensen, A., Dowty, M.E., Banker, M.E., Juba, B., Jussif, J., Lin, T., Vincent, F., Czerwinski, R.M., Casimiro-Garcia, A., Unwalla, R., Trujillo, J.I., Liang, S., Balbo, P., Che, Y., Gilbert, A.M., Brown, M.F., Hayward, M., Montgomery, J., Leung, L., Yang, X., Soucy, S., Hegen, M., Coe, J., Langille, J., Vajdos, F., Chrencik, J., Telliez, J.B. J. Med. Chem.