CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.718 | Isopropylmalate Dehydrogenase |
|
3.40.718.10 | Isopropylmalate Dehydrogenase |
Domain Context
CATH Clusters
| Superfamily | Isopropylmalate Dehydrogenase |
| Functional Family | Isocitrate dehydrogenase [NADP] |
Enzyme Information
| 1.1.1.42 |
Isocitrate dehydrogenase (NADP(+)).
based on mapping to UniProt O75874
Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.
-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.
|
UniProtKB Entries (1)
| O75874 |
IDHC_HUMAN
Homo sapiens
Isocitrate dehydrogenase [NADP] cytoplasmic
|
PDB Structure
| PDB | 5TQH |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1.
ACS Med Chem Lett
|