CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.70 | Cathepsin B; Chain A |
|
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases |
| Functional Family | Cathepsin S |
Enzyme Information
| 3.4.22.27 |
Cathepsin S.
based on mapping to UniProt P25774
Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
-!- A lysosomal cysteine endopeptidase that is unusual among such enzymes for its stability to neutral pH. -!- Belongs to peptidase family C1.
|
UniProtKB Entries (1)
| P25774 |
CATS_HUMAN
Homo sapiens
Cathepsin S
|
PDB Structure
| PDB | 5QBV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors
Bioorg.Med.Chem.Lett.
|