CATH Domain 5otfA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9Y5S2

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9Y5S2

MRCKB_HUMAN

Homo sapiens

Serine/threonine-protein kinase MRCK beta

PDB Structure

PDB	5OTF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer. Unbekandt, M., Belshaw, S., Bower, J., Clarke, M., Cordes, J., Crighton, D., Croft, D.R., Drysdale, M.J., Garnett, M.J., Gill, K., Gray, C., Greenhalgh, D.A., Hall, J.A.M., Konczal, J., Lilla, S., McArthur, D., McConnell, P., McDonald, L., McGarry, L., McKinnon, H., McMenemy, C., Mezna, M., Morrice, N.A., Munro, J., Naylor, G., Rath, N., Schuttelkopf, A.W., Sime, M., Olson, M.F. Cancer Res.