CATH Domain 5osyB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.2240	mRNA decapping enzyme DcpS N-terminal fold
	3.30.2240.10	mRNA decapping enzyme DcpS N-terminal domain

Domain Context

CATH Clusters

Superfamily	mRNA decapping enzyme DcpS N-terminal domain
Functional Family

Enzyme Information

3.6.1.59

5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] diphosphatase.

based on mapping to UniProt Q96C86

A 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA] + H(2)O = N(7)- methylguanosine 5'-phosphate + a 5'-diphospho-[mRNA].

-!- The enzyme removes (decaps) the N(7)-methylguanosine 5-phosphate cap from an mRNA degraded to a maximal length of 10 nucleotides. -!- Decapping is an important process in the control of eukaryotic mRNA degradation. -!- The enzyme functions to clear the cell of cap structure following decay of the RNA body. -!- The nematode enzyme can also decap triply methylated substrates, 5'-(N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-[mRNA]. -!- Formerly EC 3.6.1.30.

UniProtKB Entries (1)

Q96C86

DCPS_HUMAN

Homo sapiens

M7GpppX diphosphatase

PDB Structure

PDB	5OSY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	5'-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. Wojtczak, B.A., Sikorski, P.J., Fac-Dabrowska, K., Nowicka, A., Warminski, M., Kubacka, D., Nowak, E., Nowotny, M., Kowalska, J., Jemielity, J. J. Am. Chem. Soc.