CATH Domain 5obkA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.50	Chitinase A; domain 3
	3.10.50.40

Domain Context

CATH Clusters

Superfamily	3.10.50.40
Functional Family

Enzyme Information

5.2.1.8

Peptidylprolyl isomerase.

based on mapping to UniProt Q13451

Peptidylproline (omega=180) = peptidylproline (omega=0).

-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q13451

FKBP5_HUMAN

Homo sapiens

Peptidyl-prolyl cis-trans isomerase FKBP5

PDB Structure

PDB	5OBK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Chemogenomic Profiling of Human and Microbial FK506-Binding Proteins. Pomplun, S., Sippel, C., Hahle, A., Tay, D., Shima, K., Klages, A., Unal, C.M., Riess, B., Toh, H.T., Hansen, G., Yoon, H.S., Bracher, A., Preiser, P., Rupp, J., Steinert, M., Hausch, F. J. Med. Chem.