CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Complement factor D |
Enzyme Information
| 3.4.21.46 |
Complement factor D.
based on mapping to UniProt P00746
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.
|
UniProtKB Entries (1)
| P00746 |
CFAD_HUMAN
Homo sapiens
Complement factor D
|
PDB Structure
| PDB | 5NAW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J. Med. Chem.
|