1 keywords

CATH Domain 5n84A02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.510 Transferase(Phosphotransferase); domain 1
Homologous Superfamily 1.10.510.10 Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Dual specificity protein kinase TTK

Enzyme Information

2.7.12.1
Dual-specificity kinase.
based on mapping to UniProt P33981
ATP + a protein = ADP + a phosphoprotein.
-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P33981
TTK_HUMAN
Homo sapiens
Dual specificity protein kinase TTK

PDB Structure

PDB 5N84
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.
Uitdehaag, J.C.M., de Man, J., Willemsen-Seegers, N., Prinsen, M.B.W., Libouban, M.A.A., Sterrenburg, J.G., de Wit, J.J.P., de Vetter, J.R.F., de Roos, J.A.D.M., Buijsman, R.C., Zaman, G.J.R.
J. Mol. Biol.