CATH Domain 5mt4A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Complement factor D

Enzyme Information

3.4.21.46

Complement factor D.

based on mapping to UniProt P00746

Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.

-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00746

CFAD_HUMAN

Homo sapiens

Complement factor D

PDB Structure

PDB	5MT4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors. Vulpetti, A., Randl, S., Rudisser, S., Ostermann, N., Erbel, P., Mac Sweeney, A., Zoller, T., Salem, B., Gerhartz, B., Cumin, F., Hommel, U., Dalvit, C., Lorthiois, E., Maibaum, J. J. Med. Chem.