CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.80 | Trefoil |
|
2.80.10 | Trefoil (Acidic Fibroblast Growth Factor, subunit A) |
|
2.80.10.50 |
Domain Context
CATH Clusters
| Superfamily | 2.80.10.50 |
| Functional Family | Botulinum neurotoxin type A |
Enzyme Information
| 3.4.24.69 |
Bontoxilysin.
based on mapping to UniProt Q45894
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.
|
UniProtKB Entries (2)
| Q45894 |
BXA2_CLOBJ
Clostridium botulinum A2 str. Kyoto
Botulinum neurotoxin type A2
|
| Q496J9 |
SV2C_HUMAN
Homo sapiens
Synaptic vesicle glycoprotein 2C
|
PDB Structure
| PDB | 5MOY |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the BoNT/A2 receptor-binding domain in complex with the luminal domain of its neuronal receptor SV2C.
Sci Rep
|
