CATH Domain 5mleA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.140	Metal-dependent hydrolases

Domain Context

CATH Clusters

Superfamily	Metal-dependent hydrolases
Functional Family	Dihydropyrimidinase-related protein 2

Enzyme Information

UniProtKB Entries (1)

DPYL2_HUMAN

Homo sapiens

Dihydropyrimidinase-related protein 2

PDB Structure

PDB	5MLE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation. Zheng, Y., Sethi, R., Mangala, L.S., Taylor, C., Goldsmith, J., Wang, M., Masuda, K., Karaminejadranjbar, M., Mannion, D., Miranda, F., Herrero-Gonzalez, S., Hellner, K., Chen, F., Alsaadi, A., Albukhari, A., Fotso, D.C., Yau, C., Jiang, D., Pradeep, S., Rodriguez-Aguayo, C., Lopez-Berestein, G., Knapp, S., Gray, N.S., Campo, L., Myers, K.A., Dhar, S., Ferguson, D., Bast, R.C., Sood, A.K., von Delft, F., Ahmed, A.A. Nat Commun