CATH Domain 5mfaA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.640	Myeloperoxidase, subunit C
	1.10.640.10	Haem peroxidase domain superfamily, animal type

Domain Context

CATH Clusters

Superfamily	Haem peroxidase domain superfamily, animal type
Functional Family	Peroxidasin homolog

Enzyme Information

1.11.2.2

Myeloperoxidase.

based on mapping to UniProt P05164

Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O.

-!- Is present in phagosomes of neutrophils and monocytes, where the hypochlorite produced is strongly bactericidal. -!- It differs from EC 1.11.1.10 in its preference for formation of hypochlorite over the chlorination of organic substrates under physiological conditions (pH 5-8). -!- Hypochlorite in turn forms a number of antimicrobial products (Cl(2), chloramines, hydroxyl radical, singlet oxygen). -!- MPO also oxidizes bromide, iodide and thiocyanate. -!- In the absence of halides, it oxidizes phenols and has a moderate peroxygenase activity toward styrene.

UniProtKB Entries (1)

P05164

PERM_HUMAN

Homo sapiens

Myeloperoxidase

PDB Structure

PDB	5MFA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of human promyeloperoxidase (proMPO) and the role of the propeptide in processing and maturation. Grishkovskaya, I., Paumann-Page, M., Tscheliessnig, R., Stampler, J., Hofbauer, S., Soudi, M., Sevcnikar, B., Oostenbrink, C., Furtmuller, P.G., Djinovic-Carugo, K., Nauseef, W.M., Obinger, C. J. Biol. Chem.