CATH Domain 5luzB02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1370	Neurolysin; domain 3
	1.10.1370.10	Neurolysin, domain 3

Domain Context

CATH Clusters

Superfamily	Neurolysin, domain 3
Functional Family	Thimet oligopeptidase 1

Enzyme Information

3.4.24.16

Neurolysin.

based on mapping to UniProt Q9BYT8

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

-!- No absolute requirement for a prolyl bond; the enzyme acts on some peptides, such as dynorphin 1-8, that do not contain proline, and does not act on some others that do. -!- Belongs to peptidase family M3.

UniProtKB Entries (1)

Q9BYT8

NEUL_HUMAN

Homo sapiens

Neurolysin, mitochondrial

PDB Structure

PDB	5LUZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin. Teixeira, P.F., Masuyer, G., Pinho, C.M., Branca, R.M.M., Kmiec, B., Wallin, C., Warmlander, S.K.T.S., Berntsson, R.P., Ankarcrona, M., Graslund, A., Lehtio, J., Stenmark, P., Glaser, E. J. Mol. Biol.