CATH Domain 5laqA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.53

3',5'-cyclic-AMP phosphodiesterase.

based on mapping to UniProt Q07343

Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.

-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

Q07343

PDE4B_HUMAN

Homo sapiens

CAMP-specific 3',5'-cyclic phosphodiesterase 4B

PDB Structure

PDB	5LAQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure-Based Discovery of Selective Inhibitors with Trypanocidal Activity. Blaazer, A.R., Singh, A.K., de Heuvel, E., Edink, E., Orrling, K.M., Veerman, J.J.N., van den Bergh, T., Jansen, C., Balasubramaniam, E., Mooij, W.J., Custers, H., Sijm, M., Tagoe, D.N.A., Kalejaiye, T.D., Munday, J.C., Tenor, H., Matheeussen, A., Wijtmans, M., Siderius, M., de Graaf, C., Maes, L., de Koning, H.P., Bailey, D.S., Sterk, G.J., de Esch, I.J.P., Brown, D.G., Leurs, R. J. Med. Chem.