CATH Domain 5in4B02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.25	UDP-galactose 4-epimerase; domain 1
	3.90.25.10	UDP-galactose 4-epimerase, domain 1

Domain Context

CATH Clusters

Superfamily	UDP-galactose 4-epimerase, domain 1
Functional Family

Enzyme Information

4.2.1.47

GDP-mannose 4,6-dehydratase.

based on mapping to UniProt O60547

GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H(2)O.

-!- Forms the first step in the biosynthesis of GDP-alpha-D-rhamnose and GDP-alpha-L-fucose. -!- In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalyzing the above reaction as well as the reaction catalyzed by EC 1.1.1.281.

UniProtKB Entries (1)

O60547

GMDS_HUMAN

Homo sapiens

GDP-mannose 4,6 dehydratase

PDB Structure

PDB	5IN4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase. Allen, J.G., Mujacic, M., Frohn, M.J., Pickrell, A.J., Kodama, P., Bagal, D., San Miguel, T., Sickmier, E.A., Osgood, S., Swietlow, A., Li, V., Jordan, J.B., Kim, K.W., Rousseau, A.C., Kim, Y.J., Caille, S., Achmatowicz, M., Thiel, O., Fotsch, C.H., Reddy, P., McCarter, J.D. Acs Chem.Biol.