CATH Domain 5iezA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.437	Apoptosis Regulator Bcl-x
	1.10.437.10	Blc2-like

Domain Context

CATH Clusters

Superfamily	Blc2-like
Functional Family	Induced myeloid leukemia cell differentiation protein Mcl-1

Enzyme Information

UniProtKB Entries (1)

MCL1_HUMAN

Homo sapiens

Induced myeloid leukemia cell differentiation protein Mcl-1

PDB Structure

PDB	5IEZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors. Lee, T., Bian, Z., Zhao, B., Hogdal, L.J., Sensintaffar, J.L., Goodwin, C.M., Belmar, J., Shaw, S., Tarr, J.C., Veerasamy, N., Matulis, S.M., Koss, B., Fischer, M.A., Arnold, A.L., Camper, D.V., Browning, C.F., Rossanese, O.W., Budhraja, A., Opferman, J., Boise, L.H., Savona, M.R., Letai, A., Olejniczak, E.T., Fesik, S.W. FEBS Lett.