CATH Domain 5i8aA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Tyrosine-protein kinase receptor

Enzyme Information

2.7.10.1

Receptor protein-tyrosine kinase.

based on mapping to UniProt P04629

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P04629

NTRK1_HUMAN

Homo sapiens

High affinity nerve growth factor receptor

PDB Structure

PDB	5I8A
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Potent, selective and orally bioavailable leucine-rich repeat kinase 2 (LRRK2) inhibitors. Greshock, T.J., Sanders, J.M., Drolet, R.E., Rajapakse, H.A., Chang, R.K., Kim, B., Rada, V.L., Tiscia, H.E., Su, H., Lai, M.T., Sur, S.M., Sanchez, R.I., Bilodeau, M.T., Renger, J.J., Kern, J.T., McCauley, J.A. Bioorg. Med. Chem. Lett.