CATH Classification

Domain Context

CATH Clusters

Superfamily Bromodomain-like
Functional Family Transcription initiation factor TFIID subunit

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P21675
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.
2.3.1.48
Histone acetyltransferase.
based on mapping to UniProt P21675
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
-!- A group of enzymes acetylating histones. -!- Several of the enzymes can also acetylate lysines in other proteins.

UniProtKB Entries (1)

P21675
TAF1_HUMAN
Homo sapiens
Transcription initiation factor TFIID subunit 1

PDB Structure

PDB 5I29
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains.
Crawford, T.D., Tsui, V., Flynn, E.M., Wang, S., Taylor, A.M., Cote, A., Audia, J.E., Beresini, M.H., Burdick, D.J., Cummings, R., Dakin, L.A., Duplessis, M., Good, A.C., Hewitt, M.C., Huang, H.R., Jayaram, H., Kiefer, J.R., Jiang, Y., Murray, J., Nasveschuk, C.G., Pardo, E., Poy, F., Romero, F.A., Tang, Y., Wang, J., Xu, Z., Zawadzke, L.E., Zhu, X., Albrecht, B.K., Magnuson, S.R., Bellon, S., Cochran, A.G.
J.Med.Chem.
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