CATH Domain 5hxbC02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.130	Archaeosine Trna-guanine Transglycosylase; Chain: A, domain 4
	2.30.130.40	LON domain-like

Domain Context

CATH Clusters

Superfamily	LON domain-like
Functional Family	Cereblon, isoform CRA_c

Enzyme Information

UniProtKB Entries (1)

DDB1_HUMAN

Homo sapiens

DNA damage-binding protein 1

PDB Structure

PDB	5HXB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase. Matyskiela, M.E., Lu, G., Ito, T., Pagarigan, B., Lu, C.C., Miller, K., Fang, W., Wang, N.Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L., Lander, G.C., Gaidarova, S., Xu, S., Ruchelman, A.L., Handa, H., Carmichael, J., Daniel, T.O., Cathers, B.E., Lopez-Girona, A., Chamberlain, P.P. Nature