CATH Domain 5htkB01

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 3 isoform 2

Enzyme Information

2.7.1.105	6-phosphofructo-2-kinase. based on mapping to UniProt O60825 ATP + D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate. -!- Not identical with EC 2.7.1.11. -!- The enzyme copurifies with EC 3.1.3.46.
3.1.3.46	Fructose-2,6-bisphosphate 2-phosphatase. based on mapping to UniProt O60825 Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate. -!- The enzyme copurifies with EC 2.7.1.105 (cf. EC 3.1.3.54).

UniProtKB Entries (1)

F262_HUMAN

Homo sapiens

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

PDB Structure

PDB	5HTK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) and the inhibitory influence of citrate on substrate binding. Crochet, R.B., Kim, J.D., Lee, H., Yim, Y.S., Kim, S.G., Neau, D., Lee, Y.H. Proteins