CATH Domain 5gxoA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.287	Helix Hairpins
	1.10.287.990	Fe,Mn superoxide dismutase (SOD) domain

Domain Context

CATH Clusters

Superfamily	Fe,Mn superoxide dismutase (SOD) domain
Functional Family	Superoxide dismutase

Enzyme Information

1.15.1.1

Superoxide dismutase.

based on mapping to UniProt P04179

2 superoxide + 2 H(+) = O(2) + H(2)O(2).

UniProtKB Entries (1)

SODM_HUMAN

Homo sapiens

Superoxide dismutase [Mn], mitochondrial

PDB Structure

PDB	5GXO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase. Lu, J., Zhang, H., Chen, X., Zou, Y., Li, J., Wang, L., Wu, M., Zang, J., Yu, Y., Zhuang, W., Xia, Q., Wang, J. Free Radic. Biol. Med.