CATH Domain 5gvkC02

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CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

UniProtKB Entries (1)

A5K8L9_PLAVS

Plasmodium vivax Sal-1

Serine hydroxymethyltransferase, putative

PDB Structure

PDB	5GVK
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures Schwertz, G., Witschel, M.C., Rottmann, M., Bonnert, R., Leartsakulpanich, U., Chitnumsub, P., Jaruwat, A., Ittarat, W., Schafer, A., Aponte, R.A., Charman, S.A., White, K.L., Kundu, A., Sadhukhan, S., Lloyd, M., Freiberg, G.M., Srikumaran, M., Siggel, M., Zwyssig, A., Chaiyen, P., Diederich, F. J. Med. Chem.