CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.25 | Alpha Horseshoe |
|
1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
|
1.25.40.20 | Ankyrin repeat-containing domain |
Domain Context
CATH Clusters
| Superfamily | Ankyrin repeat-containing domain |
| Functional Family | Poly [ADP-ribose] polymerase |
Enzyme Information
| 2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt O95271
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
|
| 2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt O95271
|
UniProtKB Entries (1)
| Q9UHP3 |
UBP25_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 25
|
PDB Structure
| PDB | 5GP7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
USP25 regulates Wnt signaling by controlling the stability of tankyrases
Genes Dev.
|
