CATH Domain 5g5jA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.630	Cytochrome p450
	1.10.630.10	Cytochrome P450

Domain Context

CATH Clusters

Superfamily	Cytochrome P450
Functional Family	Cytochrome P450 3A4

Enzyme Information

1.14.14.56	1,8-cineole 2-exo-monooxygenase. based on mapping to UniProt P08684 1,8-cineole + [reduced NADPH--hemoprotein reductase] + O(2) = 2-exo- hydroxy-1,8-cineole + [oxidized NADPH--hemoprotein reductase] + H(2)O. -!- The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including stereoids, fatty acids, and xenobiotics. -!- Cf. EC 1.14.14.55, EC 1.14.14.57 and EC 1.14.14.73. -!- Formerly EC 1.14.13.157.
1.14.14.55	Quinine 3-monooxygenase. based on mapping to UniProt P08684 Quinine + [reduced NADPH--hemoprotein reductase] + O(2) = 3-hydroxyquinine + [oxidized NADPH--hemoprotein reductase] + H(2)O. -!- Formerly EC 1.14.13.67.
1.14.14.-	With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. based on mapping to UniProt P08684
1.14.14.73	Albendazole monooxygenase (sufoxide-forming). based on mapping to UniProt P08684 (1) Albendazole + [reduced NADPH--hemoprotein reductase] + O(2) = albendazole S-oxide + [oxidized NADPH--hemoprotein reductase] + H(2)O. (2) Fenbendazole + [reduced NADPH--hemoprotein reductase] + O(2) = fenbendazole S-oxide + [oxidized NADPH--hemoprotein reductase] + H(2)O. -!- This is one of the activities carried out by some microsomal cytochrome P450 monooxygenases. -!- A similar conversion is also carried out by a different microsomal enzyme (EC 1.14.13.32), but it is estimated that cytochrome P450s are responsible for 70% of the activity.

UniProtKB Entries (1)

CP3A4_HUMAN

Homo sapiens

Cytochrome P450 3A4

PDB Structure

PDB	5G5J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria. Guo, Z., Sevrioukova, I.F., Denisov, I.G., Zhang, X., Chiu, T.L., Thomas, D.G., Hanse, E.A., Cuellar, R.A.D., Grinkova, Y.V., Langenfeld, V.W., Swedien, D.S., Stamschror, J.D., Alvarez, J., Luna, F., Galvan, A., Bae, Y.K., Wulfkuhle, J.D., Gallagher, R.I., Petricoin, E.F., Norris, B., Flory, C.M., Schumacher, R.J., O'Sullivan, M.G., Cao, Q., Chu, H., Lipscomb, J.D., Atkins, W.M., Gupta, K., Kelekar, A., Blair, I.A., Capdevila, J.H., Falck, J.R., Sligar, S.G., Poulos, T.L., Georg, G.I., Ambrose, E., Potter, D.A. Cell Chem Biol