CATH Domain 5fp8A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.650	Cupin

Domain Context

CATH Clusters

Superfamily	Cupin
Functional Family	Lysine-specific demethylase 4D

Enzyme Information

1.14.11.-

With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

based on mapping to UniProt Q6B0I6

UniProtKB Entries (1)

KDM4D_HUMAN

Homo sapiens

Lysine-specific demethylase 4D

PDB Structure

PDB	5FP8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Cell Penetrant Inhibitors of the Kdm4 and Kdm5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-Pyridine Carboxylate Derivatives. Westaway, S.M., Preston, A.G.S., Barker, M.D., Brown, F., Brown, J.A., Campbell, M., Chung, C., Diallo, H., Douault, C., Drewes, G., Eagle, R., Gordon, L., Haslam, C., Hayhow, T.G., Humphreys, P.G., Joberty, G., Katso, R., Kruidenier, L., Leveridge, M., Liddle, J., Mosley, J., Muelbaier, M., Randle, R., Rioja, I., Rueger, A., Seal, G.A., Sheppard, R.J., Singh, O., Taylor, J., Thomas, P., Thomson, D., Wilson, D.M., Lee, K., Prinjha, R.K. J.Med.Chem.