CATH Domain 5femB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1220	TPP-binding domain

Domain Context

CATH Clusters

Superfamily	TPP-binding domain
Functional Family	Acetolactate synthase

Enzyme Information

2.2.1.6

Acetolactate synthase.

based on mapping to UniProt P07342

2 pyruvate = 2-acetolactate + CO(2).

-!- The reaction shown is in the pathway of biosynthesis of valine. -!- The enzyme can also transfer the acetaldehyde from pyruvate to 2-oxobutanoate, forming 2-ethyl-2-hydroxy-3-oxobutanoate, also known as 2-aceto-2-hydroxybutanoate, a reaction in the biosynthesis of isoleucine. -!- Formerly EC 4.1.3.18.

UniProtKB Entries (1)

P07342

ILVB_YEAST

Saccharomyces cerevisiae S288C

Acetolactate synthase catalytic subunit, mitochondrial

PDB Structure

PDB	5FEM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase. Lonhienne, T., Nouwens, A., Williams, C.M., Fraser, J.A., Lee, Y.T., West, N.P., Guddat, L.W. Angew.Chem.Int.Ed.Engl.