CATH Domain 5en4A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	17-beta-hydroxysteroid dehydrogenase 14

Enzyme Information

1.1.1.-

With NAD(+) or NADP(+) as acceptor.

based on mapping to UniProt Q9BPX1

UniProtKB Entries (1)

DHB14_HUMAN

Homo sapiens

17-beta-hydroxysteroid dehydrogenase 14

PDB Structure

PDB	5EN4
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	First Structure-Activity Relationship of 17 beta-Hydroxysteroid Dehydrogenase Type 14 Nonsteroidal Inhibitors and Crystal Structures in Complex with the Enzyme. Braun, F., Bertoletti, N., Moller, G., Adamski, J., Steinmetzer, T., Salah, M., Abdelsamie, A.S., van Koppen, C.J., Heine, A., Klebe, G., Marchais-Oberwinkler, S. J. Med. Chem.